Objective: To analyze the effectiveness of hemiarthroplasty compared to total arthroplasty in the treatment of hip fractures. Methodology: Systematic literature review, with a quantitative and qualitative approach to the data collected, which was structured according to the guidelines of the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA): “total hip arthroplasty” and ‘hemiarthroplasty’ with ‘AND’ and ‘OR’ combinations. Results: The five articles selected evaluated the effectiveness of hemiarthroplasty and total hip arthroplasty techniques using the WOMAC score, Harris Hip Score (HHS), SF-36 (Short Form Health Survey 36) and/or Visual analogue scale (VAS). Total arthroplasty showed better results in most studies (p<0.01). Conclusion: Total arthroplasty was considered the procedure of choice, especially for active elderly patients.

This dissertation investigates the prevalence and contributing factors of obesity among young children in Uzbekistan, aiming to address the critical issue of increasing obesity rates in this demographic. Employing a quantitative approach, the study analyzes body mass index (BMI) data alongside dietary habits, physical activity levels, and socioeconomic factors affecting children's health. The findings reveal a significant prevalence of obesity in young children, which is closely linked to poor nutrition, insufficient physical activity, and socioeconomic disparities. Notably, a substantial percentage of the population exhibited unhealthy dietary patterns and low engagement in physical exercise, underscoring the multifaceted nature of this public health challenge. The implications of this research are profound, as it highlights the urgent need for targeted interventions and policy reforms to promote healthier lifestyles and reduce obesity rates in Uzbekistan. By addressing the specific factors contributing to childhood obesity, this study underscores the importance of integrating nutrition education and physical activity programs within healthcare initiatives. Furthermore, the results contribute to the broader discourse on childhood health issues in developing countries, providing a framework for future research and intervention strategies aimed at ameliorating the obesity epidemic and fostering a healthier future generation.

Kartagener's syndrome (KS) is a rare hereditary disease characterized by a triad of symptoms: primary ciliary dyskinesia, situs inversus, and chronic respiratory infections. This article presents a family case of KS in children, emphasizing the clinical features, diagnostic challenges, and management strategies. The study analyzes the genetic aspects, pathophysiology, and progression of the disease in affected siblings. Special attention is given to respiratory complications, recurrent infections, and the impact on the quality of life. Early diagnosis and comprehensive therapeutic approaches, including airway clearance techniques and antibiotic prophylaxis, are crucial for improving long-term outcomes in children with KS.

Pathophysiology, a foundational subject in medical and health sciences education, explores the mechanisms underlying disease processes. Despite its importance, the complexity and volume of content often pose significant challenges for students, leading to varied learning outcomes. Traditional teaching methods, which adopt a uniform approach for all learners, frequently fail to address the diverse needs, backgrounds, and learning styles of students. Personalized learning, an innovative educational strategy that tailors instruction to individual learners, offers a promising solution to these challenges. By leveraging adaptive technologies, data analytics, and customized teaching methods, personalized learning can transform pathophysiology education, making it more engaging, effective, and accessible. This article examines the principles of personalized learning, its application in pathophysiology, and the potential benefits and challenges of its implementation. Through a student-centered approach, personalized learning has the potential to enhance comprehension, retention, and critical thinking skills, ultimately preparing students for the demands of clinical practice. The integration of emerging technologies, such as artificial intelligence and virtual reality, further underscores the transformative potential of personalized learning in shaping the future of medical education.

Objectives: The aim of this systematic review is to evaluate the effectiveness of the use of orthoses in the treatment of pediatric flatfoot.

Methodology: A systematic review was carried out in the online databases Cochrane Library, EMBASE, CINAHL, Medline and PubMed, using the following terms: flatfoot AND pediatric AND Orthotic

Devices. There were no limitations on gender, date or language. All results up to

February 1, 2024 were included.

Results: 213 patients under the age of 18 were included in this study. The use of medial arch support insoles proved to be effective in the treatment of flat feet in children, with an improvement in ankle internal rotation angles and knee internal and external rotation.

Conclusion: The use of orthoses has shown good results and is a reproducible and reliable approach, especially in pre- school patients who have been using them for more than 12 months, with improvements in gait, alignment and coordination of the lower limbs.

The symptoms of esophageal hypersensitivity and refractory gastroesophageal reflux disease (rGERD) become aggressive clinical targets for treatment even when patients have the most effective acid suppression therapy. Science now supports antidepressant pain modulators such as tricyclic antidepressants (TCAs) and selective serotonin reuptake inhibitors (SSRIs) as potential therapeutic medications because they control esophageal nociceptive signals and central pain signals within the brain. This extensive review examines the functional roles which these treatments perform when treating esophageal hypersensitivity along with rGERD and conducts an assessment of their effectiveness and security data with clinical implications. The review analyzed findings from randomized controlled trials and meta-analyses and observational studies which were published in prestigious journals. The evaluations based on statistics demonstrated how antidepressants as pain modulators perform against standard GERD therapies while assessing symptom control along with life quality benefits and potential side effects in patients. The review examines visceral pain modulation neurophysiology to demonstrate potential treatment approaches for individual patients. Studies reveal that TCA medications together with SSRI medications successfully decrease esophageal pain experiences from central nervous system and peripheral nervous system mechanisms while offering better treatment outcomes to PPI non-responsive patient populations. Clinical research involving low-dose antidepressants showed both statistically relevant improvements in heartburn severity scores as well as pain intensity measurements from the chest area for treatment participants. More research needs to address safety questions and ideal medications doses along with long-term safety matters. The research demonstrates how antidepressant pain modulators serve as promising complementary therapies for treating esophageal hypersensitivity and rGERD while recommending new treatment approaches. Future research needs to improve selection criteria for patients while discovering the most effective treatment plans and increasing evidence-based applications for better clinical results. These research outcomes enable the advancement of comprehension regarding neurogastroenterology critical connection with psychopharmacology thus producing new multidisciplinary treatment models.

Traumatic Brain Injury (TBI) is widely recognized for its profound impact on brain function, but its consequences often extend beyond the brain to affect various extracranial systems. This narrative review explores the extracranial effects of TBI, focusing on the cardiovascular, respiratory, endocrine, and musculoskeletal systems, as well as immune response and metabolic changes. The review synthesizes current literature on how TBI-induced pathophysiological changes extend throughout the body and influence long-term outcomes, including physical and mental health. The interplay between intracranial injury and extracranial effects is critical for understanding the full scope of TBI’s impact. Future research should emphasize the development of comprehensive treatment protocols that address both intracranial and extracranial effects to improve outcomes for TBI patients.

In Uzbekistan, the sphere of ART is relatively new and the problems of pregnancy after ART procedures remain both a socio-psychological and economic problem. The article discusses the effect of melatonin use on the probability of pregnancy as the first clinical trials in this country. A comparative analysis of the results between groups of women who used melatonin and a control group is made. The physiologic mechanisms of melatonin action, its effect on reproductive health and the prospects for its use in clinical practice are highlighted. Clinical trials using melatonin in the field of assisted reproductive technologies (ART) are conducted for the first time in Uzbekistan. This is an innovative approach aimed at studying the effectiveness and safety of this drug in improving reproductive indicators in patients.

Daltonism is a vision disorder in which the eye is unable to perceive one or more primary colors. This disorder is caused by a defect in the X chromosome. However, this is not the only cause of the disease. Color perception may be impaired due to eye or nervous diseases, traumatic brain injury, severe flu, stroke, or heart attack.

This pathology was named after the English chemist John Dalton, who also suffered from this disease, like his relatives, discovered and described the pathology in a book.

Cardiovascular diseases (CVDs) and obesity are leading causes of morbidity and mortality worldwide. Over the past several decades, while CVD-related deaths have declined in high-income countries, they have significantly increased in low- and middle-income countries, including Pakistan, which bears nearly 80% of the global burden. Obesity, a key modifiable risk factor for CVDs, has emerged as a serious public health challenge in Pakistan due to sedentary lifestyles, unhealthy diets, and lack of awareness. Despite the growing prevalence of obesity and its strong association with cardiovascular diseases, minimal attention has been given to preventive strategies in South Asia, particularly in Pakistan. Additionally, economic and political instability further exacerbates the rising trends of CVDs and obesity in the country. Practical efforts are required to enhance the understanding of risk factors such as poor diet, physical inactivity, and tobacco use while promoting obesity prevention through targeted interventions. This paper reviews the major modifiable risk factors in Pakistan, highlights available preventive services, and discusses evidence-based strategies for reducing the burden of both cardiovascular diseases and obesity at the population level.