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Effect Of Melatonin on Pregnancy Onset: A Comparative Analysis of Efficacy

Abdurakhmanova Sitora Ibragimovna
Associate Professor, Department of Obstetrics and Gynecology, Tashkent State Dental Institute, Tashkent, Uzbekistan
Temirgaliev Azamat Amirovich
Assistant, Israel Medical Center of Human Reproduction and Family Health, Tashkent, Uzbekistan
DOI Crossref DOI 10.37547/tajmspr/Volume07Issue03-08
tajmspr 2025
VOL. 7 / NO. 03 MARCH
FULL TEXT PP. 46-48
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VOLUME 7
ISSUE 03
YEAR 2025
PAGES 46-48
RESEARCH OVERVIEW

Abstract

In Uzbekistan, the sphere of ART is relatively new and the problems of pregnancy after ART procedures remain both a socio-psychological and economic problem. The article discusses the effect of melatonin use on the probability of pregnancy as the first clinical trials in this country. A comparative analysis of the results between groups of women who used melatonin and a control group is made. The physiologic mechanisms of melatonin action, its effect on reproductive health and the prospects for its use in clinical practice are highlighted. Clinical trials using melatonin in the field of assisted reproductive technologies (ART) are conducted for the first time in Uzbekistan. This is an innovative approach aimed at studying the effectiveness and safety of this drug in improving reproductive indicators in patients.

RESEARCH TOPICS

Keywords

IVF melatonin pregnancy

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References

  1. Reiter, R. J., Tan, D. X., & Manchester, L. C. (2013). Melatonin in the context of the ovary: Physiological and pathophysiological implications. Fertility and Sterility, 100(4), 1011-1018.
  2. Tamura, H., Nakamura, Y., & Korkmaz, A. (2009). Melatonin and the ovary: Physiological and pathophysiological implications. Fertil Steril, 92(1), 328-343.
  3. Ortiz, Á., Espino, J., Bejarano, I., et al. (2011). The role of melatonin in preventing oxidative stress and apoptosis in oocytes. Reproductive Sciences, 18(9), 881-890.
  4. Chen, M., Chang, C., & Gung, C. (2013). Role of melatonin in improving oocyte quality and embryo development in women undergoing in vitro fertilization (IVF). International Journal of Molecular Sciences, 14(6), 11674-11691.
  5. Jahromi, B. N., & Sadeghi, S. (2015). The impact of melatonin on oocyte quality and pregnancy outcomes in women undergoing assisted reproductive technology: A systematic review. Journal of Obstetrics and Gynecology Research, 41(12), 1778-1786.
  6. Arendt, J. (2010). Melatonin, circadian rhythms, and sleep. The New England Journal of Medicine, 343(15), 1114-1116.
  7. Pandi-Perumal, S. R., Srinivasan, V., & Maestroni, G. J. M. (2006). Role of melatonin in immunomodulation: Actions at the cellular and molecular levels. Journal of Clinical Endocrinology and Metabolism, 91(2), 167-175.
  8. Wang, F., Tian, X., Zhang, L., et al. (2014). Beneficial effects of melatonin on in vitro maturation of mouse oocytes: Involvement of the anti-oxidative and anti-apoptotic mechanisms. PLoS ONE, 9(1), e87664.
  9. Pacchiarotti, A., Carlomagno, G., Antonini, G., et al. (2016). Role of melatonin in improving oocyte quality and IVF outcomes in women with diminished ovarian reserve: A randomized trial. Gynecological Endocrinology, 32(2), 103-107.
  10. Okatani, Y., Wakatsuki, A., Reiter, R. J., et al. (2001). Protective effect of melatonin against oxidative damage of human umbilical arterial blood. Molecular and Cellular Endocrinology, 181(1-2), 103-109.