The existing systems of health care in the world today are finding it difficult to cope with the historical strain in their operations whereby administrative and clinical inefficiencies are liable about 25% of the annual health care expenditure. Customary packets of analysis are not generally as dexterous as the multi-modal and quick data that is generated by the current Electronic Health Records (EHR). Purpose: The application of state-of-the-art Data Science techniques based on optimizing the predictive model precision and maximizing the systemic performance of healthcare analytics will be the research problem. Methodology: The present research relies on the evaluation of ensemble learning systems and deep neural networks depending on principles of AI-based engineering and infrastructural solidity. The performance metrics to be used during the study are Area Under the Curve (AUC), and throughput rate to determine the effectiveness of this type of models used in the actual clinical environment. Results: According to the analysis, the AI predictive models are better at identifying sepsis at infancy and chronic heart diseases; its AUC value is 0.85-0.92, which is more advanced compared to 0.70, the typical clinical scoring. In addition, performance optimization algorithms were also capable of reducing patient waiting time by 15-20 percent and reducing the efficiency in bed utilization by 12 percent, which all eased the hospital bottlenecks. Data science systems entail the inclusion of strong data science systems to ensure the creation of robust healthcare infrastructure. Even after the set of questions about the privacy of the data and the transparency of the algorithms would still remain critical issues, the transition to predictive and AI-based systems offers a measurable roadmap of the course toward sustainable clinical performance and reduced wastes in the operation. Ultimately, the integration of these AI-driven frameworks serves as a catalyst for a proactive rather than reactive medical paradigm. By harmonizing high-speed computational power with clinical intuition, healthcare providers can mitigate human error and standardize care across diverse demographics. This shift not only addresses immediate fiscal leaks but also establishes a scalable blueprint for global health equity. Consequently, the maturation of these technologies signifies a pivotal evolution toward an automated, precision-oriented future in public health management.