★★★★★★★★★★★★★★★★★★★★★★★★★★★★★★★★★★★★★★★★★★★★★★★★★★Open research. Global perspectives.
Medical Sciences OPEN ACCESS

Study Of The General Pharmacological Properties Of A New Antiarrhythmic N-Deacetyllappaconitine With Oral Administration

Tolmas Tolibovich Khamroev
Institute of Chemistry of Plant Substances, Academy of Sciences of Republic of Uzbekistan, Tashkent
Zafar Isomiddinovich Sanoev
Institute of Chemistry of Plant Substances, Academy of Sciences of Republic of Uzbekistan, Tashkent
Ibrokhim To’ychievich Abdinazarov
Institute of Chemistry of Plant Substances, Academy of Sciences of Republic of Uzbekistan, Tashkent
Sukhrob Davlatyor O’gli Rakhimboev
Institute of Chemistry of Plant Substances, Academy of Sciences of Republic of Uzbekistan, Tashkent
Sokhib Zamon O’gli Rashidov
Institute of Chemistry of Plant Substances, Academy of Sciences of Republic of Uzbekistan, Tashkent
tajmspr 2021
VOL. 3 / NO. 03 MARCH
VOLUME 3
ISSUE 03
YEAR 2021
PAGES 60-64

Abstract

The aim of the present study was to study a new antiarrhythmic effect of N-deacetyllappaconitine on the general pharmacological irritant effect on the skin, when applied to the conjunctival sac of the eye, mucosal hyperemia and lacrimation, cumulative, allergenic and diuretic effects. At the same time, it does not cause changes, which makes it more secure.

Keywords

N-deacetyllappaconitine local irritant cumulative allergenic diuretic effect

Downloads

Download data is not yet available.

References

  1. Klyuzhev V.M., Ardashev V.N., Bryuhoveckij A.G. Ishemicheskaya bolezn' serdca. M.: Medicina, 2004. 304 p.
  2. Miller O.N., Bahmet'eva T.A., Guseva I.A., Egorov A.B., Skurihina O.N., Tereshchenko A.V. Prichinno-sledstvennye svyazi vozniknoveniya fibrillyacii predserdij u bol'nyh arterial'noj gipertenziej. Vestnik aritmologii. 2006. № 44. p. 44-48.
  3. Akhiyarov A.A., Lobov A.N., Ivanov S.P., Spirikhin L.V., Gabbasov T.M., Tsyrlina E.M., Yunusov M.S., Valiev N.V., Sadikov A.Z., Sagdullaev S.S. Antiarrhythmic agents based on diterpenoid alkaloid lappaconitine. protonation of n-deacethyllappaconitine in methanol solutions. Russian Chemical Bulletin. 2020. Т. 69. № 3. p. 567-571.
  4. Sanoev, Z.I.,Khamroev, T.T.,Djaxangirov, F.N.,Sadikov, A.Z.,Sagdullaev, S.S. Antiarrhythmic activity of n-deacetyllappaconitine when administered orally. Annals of the Romanian Society for Cell Biology,2021,25(2), pp. 2339–2346
  5. European Convention for the Protection of Vertebrate Animals Used for Experimental and Other Scientific Purposes, ETS №123, Strasbourg (1986).
  6. Khabriev R.U. (Ed.). Methodological guide for experimental (preclinical) study of new pharmacological substances. M. 2005. p. 832
CONTINUE EXPLORING

Most read articles by the same author(s)

Explore other published research by the authors of this article.