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Clinical Aspects And Immune Status Of Adult Patients With Measles After The Covid-19 Pandemic

Rahimova Mohinur Ravshanovna
Republican Specialized Scientific and Practical Medical Center for Epidemiology, Microbiology, Infectious and Parasitic Diseases, Tashkent, Uzbekistan
DOI Crossref DOI 10.37547/tajmspr/Volume07Issue12-11
tajmspr 2025
VOL. 7 / NO. 12 DECEMBER
FULL TEXT PP. 76-82
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VOLUME 7
ISSUE 12
YEAR 2025
PAGES 76-82
RESEARCH OVERVIEW

Abstract

Background: In recent years, Uzbekistan has faced a renewed challenge in controlling measles, with a noticeable rise in adult cases after the COVID-19 pandemic. While measles is typically regarded as a childhood disease, the infection in adults often follows a more severe course and is accompanied by frequent complications. The reduction in population immunity, combined with incomplete vaccination histories, has contributed to the re-emergence of measles among adults. Evaluating both the clinical presentation and serological immune response, particularly measles-specific IgG antibodies, is crucial for understanding current patterns of susceptibility. Objective: To describe the clinical and immunological characteristics of measles in adults in Uzbekistan during 2023–2025, with particular attention to disease severity, complications, and IgG antibody profiles. Methods: A prospective observational study was carried out at the 3rd clinic of Tashkent Me and several regional clinics. The study consisted of 187 adults aged 18–59 years with laboratory-confirmed measles. Diagnosis was based on characteristic clinical features and the detection of measles-specific IgM and IgG antibodies using enzyme-linked immunosorbent assay (ELISA). Each patient underwent a detailed clinical assessment and standard laboratory testing. IgG titers were measured at admission and again on days 10–14 to evaluate immune response and seroconversion. Results: Most patients were young adults (mean age 28.4 ± 9.7 years); 72 % reported no prior vaccination. Fever above 39 °C, cough, conjunctivitis, and generalized rash were the predominant symptoms. Complications developed in 37.9 % of patients, most often pneumonia, hepatitis, or gastrointestinal involvement. Laboratory findings commonly showed leukopenia and moderate elevation of liver enzymes. At admission, 26 % of patients had no significant measles-specific IgG, indicating susceptibility despite presumed prior exposure. Among those with paired sera, 84 % demonstrated a fourfold increase in IgG titers during convalescence, confirming an active immune response. Conclusion: Adult measles in Uzbekistan during the post-pandemic period was characterized by a moderate to severe clinical course and a high rate of complications. The detection of low IgG levels in a considerable proportion of patients highlights existing immunity gaps among adults. Incorporating IgG screening into routine epidemiological surveillance and extending vaccination programs to adults could help identify at-risk groups and strengthen measles control in the upcoming years.

RESEARCH TOPICS

Keywords

Measles Adults Clinical course

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References

  1. Basina, V. V., Esaulenko, E. V., Novak, K. E., & Bryantseva, E. V. (2021). Clinical and epidemiological features of measles in adults in the modern period. Journal of Infectology, 13(2), 70–78. https://doi.org/10.22625/2072-6732-2021-13-2-70-78
  2. Gavi, the Vaccine Alliance. (2023, September 12). Measles is surging, and Uzbekistan is bolstering its defences. Retrieved from https://www.gavi.org/vaccineswork/measles-surging-and-uzbekistan-bolstering-its-defences
  3. Ivanova, I. A., Ponezheva, Zh. B., Kozlova, M. S., & Terekhov, A. M. (2018). Features of the course of measles in adults. Lechashchiy Vrach, 11, 12–18.
  4. Kharchenko, G. A., & Kimirilova, O. G. (2019). Clinical and epidemiological features of measles in children of the Astrakhan region. Children’s Infections, 18(3), 31–36. https://doi.org/10.22627/2072-8107-2019-18-3-31-36
  5. Khudoydodova, S. I., Mamatkulova, G. U., & Karimova, M. Z. (2024). Clinical manifestations of measles with involvement of the digestive system in adults in Uzbekistan. Clinical Medicine of Infectious Diseases, 4(1), 23–29.
  6. Ministry of Health of the Republic of Uzbekistan. (2024). Republican measles registry: Annual epidemiological bulletin (January 2023 – November 2024). Tashkent: Department of Epidemiological Surveillance and Immunoprophylaxis.
  7. Rakhmatullaeva, Sh. B., & Okhunjonova, K. Kh. (2025). Features of measles course in adults at the modern stage. Clinical Medicine (Tashkent Medical Academy Journal), 5, 114–116. ISSN 2181-7812.
  8. State Committee of the Republic of Uzbekistan on Statistics. (2024). Population and demographic data. Retrieved from https://stat.uz/en/
  9. UNICEF. (2024). In Focus: Immunization in Europe and Central Asia. Geneva: United Nations Children’s Fund. Retrieved from https://www.unicef.org/eca/reports/focus-immunization-2024
  10. World Health Organization & UNICEF. (2023). Uzbekistan: WHO–UNICEF estimates of national immunization coverage (WUENIC). Geneva: WHO. Retrieved from https://immunizationdata.who.int/pages/profiles/uzb.html
  11. World Health Organization. (2024). Measles and rubella surveillance data. Geneva: WHO. Retrieved from https://www.who.int/teams/immunization-vaccines-and-biologicals/immunization-analysis-and-insights/surveillance/data.