Prenatal stress and neurodevelopmental disorders: neuroanatomical and psychiatric outcomes
Abstract
Prenatal stress has been increasingly recognized as a significant factor influencing fetal brain development, leading to long-term neuroanatomical and psychiatric consequences. This literature review synthesizes current research on the impact of maternal stress during pregnancy on offspring neurodevelopment, focusing on structural brain abnormalities and associated psychiatric disorders. Evidence suggests that prenatal stress disrupts neurogenesis, synaptic plasticity, and hypothalamic-pituitary-adrenal (HPA) axis function, increasing susceptibility to conditions such as autism spectrum disorder (ASD), attention-deficit/hyperactivity disorder (ADHD), schizophrenia, and mood disorders. Understanding these mechanisms is crucial for developing early intervention strategies to mitigate adverse outcomes.
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References
- Arnsten, A. F. T. (2009). Stress signalling pathways that impair prefrontal cortex structure and function. Nature Reviews Neuroscience, 10(6), 410-422. https://doi.org/10.1038/nrn2648
- Beversdorf, D. Q., Stevens, H. E., & Jones, K. L. (2018). Prenatal stress, maternal immune dysregulation, and their association with autism spectrum disorders. Current Psychiatry Reports, 20(9), 76. https://doi.org/10.1007/s11920-018-0945-4
- Buss, C., Davis, E. P., Muftuler, L. T., Head, K., & Sandman, C. A. (2012). High pregnancy anxiety during mid-gestation is associated with decreased gray matter density in 6-9-year-old children. Psychoneuroendocrinology, 35(1), 141-153. https://doi.org/10.1016/j.psyneuen.2009.07.010
- Fatemi, S. H., & Folsom, T. D. (2009). The neurodevelopmental hypothesis of schizophrenia, revisited. Schizophrenia Bulletin, 35(3), 528-548. https://doi.org/10.1093/schbul/sbn187
- Glover, V. (2011). Annual research review: Prenatal stress and the origins of psychopathology: An evolutionary perspective. Journal of Child Psychology and Psychiatry, 52(4), 356-367. https://doi.org/10.1111/j.1469-7610.2011.02371.x
- Lupien, S. J., McEwen, B. S., Gunnar, M. R., & Heim, C. (2009). Effects of stress throughout the lifespan on the brain, behaviour and cognition. Nature Reviews Neuroscience, 10(6), 434-445. https://doi.org/10.1038/nrn2639
- Qiu, A., Rifkin-Graboi, A., Chen, H., Chong, Y. S., Kwek, K., Gluckman, P. D., Fortier, M. V., & Meaney, M. J. (2015). Maternal anxiety and infants' hippocampal development: Timing matters. Translational Psychiatry, 5(3), e552. https://doi.org/10.1038/tp.2015.44