IMPACT OF GUT MICROBIOTA ON THE GUT-BRAIN AXIS IN NEUROLOGICAL DISORDERS AND THE ROLE OF ENDOCRINE AND METABOLIC MARKERS
Abstract
This review highlights the critical importance of gut microbiota in modulating the gut-brain axis and its consequences for neurological disorders, including autism, Alzheimer's disease, and Parkinson's disease. New evidence is just beginning to suggest that gut microbiota may affect brain functioning through the intricate pathways of the immune, endocrine, and metabolic systems. This review discusses how alterations in gut microbiota composition may lead to aberrant endocrine responses and changes in metabolic markers contributing to neuroinflammation, neurodegeneration, and behavioural symptoms related to these diseases. This study will look at the potential targeting of the gut microbiome as a therapeutic strategy for neurological disorders through bidirectional interactions between the gut and the central nervous system. These findings have relevance toward understanding the gut-brain axis in the search for new biomarkers and development of personalised interventions in better promotion of neurological health.
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- Clarke, G., Grenham, S., Scully, P., Fitzgerald, P., Moloney, R. D., Shanahan, F., Dinan, T. G., & Cryan, J. F. (2013). The microbiome-gut-brain axis during early life regulates the hippocampal serotonergic system in a sex-dependent manner. Molecular Psychiatry, 18(6), 666-673. https://doi.org/10.1038/mp.2012.77
- Cryan, J. F., O’Riordan, K. J., Cowan, C. S., Sandhu, K. V., Bastiaanssen, T. F., Boehme, M., ... & Dinan, T. G. (2019). The microbiota-gut-brain axis: From composition to function. Microbiome, 7(1), 1-27. https://doi.org/10.1186/s40168-019-0479-2
- Hsiao, E. Y., McBride, S. W., Hsien, S., Sharon, G., Hyde, E. R., McCue, T., ... & Mazmanian, S. K. (2013). Microbiota modulate behavioral and physiological abnormalities associated with neurodevelopmental disorders. Cell, 155(7), 1451-1463. https://doi.org/10.1016/j.cell.2013.11.024
- Keshavarzian, A., Green, S. J., Engen, P. A., Voigt, R. M., Naqib, A., Forsyth, C. B., ... & Mutlu, E. (2015). Colonic bacteria, inflammation, and motor function in Parkinson’s disease. Movement Disorders, 30(10), 1333-1340. https://doi.org/10.1002/mds.26307
- Mayer, E. A., Knight, R., Mazmanian, S. K., Cryan, J. F., & Tillisch, K. (2020). Gut/brain axis and the microbiota. The Journal of Clinical Investigation, 128(3), 926-938. https://doi.org/10.1172/JCI90912
- Needham, B. D., & Kaddurah-Daouk, R. (2020). Gut microbiome and stress response in neurological disorders: Cortisol, neuroinflammation, and therapeutic insights. Psychopharmacology, 237(5), 1557-1565. https://doi.org/10.1007/s00213-020-05493-8
- Pellegrini, C., Antonioli, L., Colucci, R., Blandizzi, C., & Fornai, M. (2018). Short-chain fatty acids and bile acids in the regulation of gut-brain communication. Neuropharmacology, 136(Part B), 137-146. https://doi.org/10.1016/j.neuropharm.2017.11.011
- Sampson, T. R., Debelius, J. W., Thron, T., Janssen, S., Shastri, G. G., Ilhan, Z. E., ... & Mazmanian, S. K. (2016). Gut microbiota regulate motor deficits and neuroinflammation in a model of Parkinson’s disease. Cell, 167(6), 1469-1480.e12. https://doi.org/10.1016/j.cell.2016.11.018
- Vogt, N. M., Kerby, R. L., Dill-McFarland, K. A., Harding, S. J., Merluzzi, A. P., Johnson, S. C., ... & Bendlin, B. B. (2017). Gut microbiome alterations in Alzheimer’s disease. Scientific Reports, 7, 13537. https://doi.org/10.1038/s41598-017-13601-y