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PLGF/ SFLT-1 Concentrations As Early Predictors Preeclampsia In Pregnancy During Pandemic Covid-19

Makhmudova Sevara Erkinovna
Samarkand State Medical Institute, Uzbekistan
Negmadjanov Baxodur Boltaevich
Samarkand State Medical Institute, Uzbekistan
DOI Crossref DOI 10.37547/TAJMSPR/Volume02Issue08-22
tajmspr 2020
VOL. 2 / NO. 08 AUGUST
FULL TEXT PP. 146-151
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VOLUME 2
ISSUE 08
YEAR 2020
PAGES 146-151
RESEARCH OVERVIEW

Abstract

The imbalance in placenta- originated angiogenic factors has been found to play an important role in
the pathogenesis of preeclampsia in recent years. Soluble fms- like tyrosine kinase 1 (sFlt-1) and
placental growth factor (PIGF) are the most studied proteins. sFlt-1, a splice variant of the vascular
endothelial growth factor (VEGF) receptor Flt-1, is a circulating antiangiogenic protein that inhibits
proangiogenic factors—VEGF and PIGF signalling in the vasculature. High levels of circulating sFlt-1 and
low levels of PIGF were observed in women with established preeclampsia and even before the onset
of clinical symptoms [1,6,9,11]

RESEARCH TOPICS

Keywords

PlGF/ SFLT-1 concentrations placenta

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