RF-MNetV2: Early and Accurate Skin Cancer Detection using Hybrid Artificial Intelligence Algorithms
Hussein Hikmat Abdulkarim , Ministry of Education – General Directorate of Financial Affairs, Baghdad, IraqAbstract
The ability to diagnose skin disease by using dermatoscopic images is growing due to advancements in AI. despite those developments, the biggest challenges are still related to class imbalance (skin cancer is rare), variable characteristics among lesions, and lack of diversity in available datasets when it comes to people's ethnicities. all of which limit how reliable the models are and limits the amount they can generalize to other populations. therefore, this research developed a hybrid classification system. this system combined a deep learning-based feature extraction method called mobilenetv2 with random forest. this allows for the derivation of highly informative features from the skin lesion images through transfer learning. the ensemble nature of the random forest also increases the classification stability and prevents overfitting. In addition to the development of the hybrid classification framework; this project also implemented several preprocessing methods. the two most important preprocessing methods include normalizing the data and implementing class balance methods. the purpose was to make sure that the best possible training data existed and ultimately increase the effectiveness of the suggested framework. experimental evaluation on the ham-10k dataset showed that the proposed Mobile-Netv2-random forest model had an average classification accuracy of approximately 97.86%. additionally, precision, recall, and f1 score values were extremely consistent. all three values demonstrate that the proposed hybrid classification framework offers a relatively simple yet effective solution. the simplicity of the proposed solution would be able to compete with some of the more complex hybrid solutions. finally, the results indicate that utilizing lightweight DLmodels with ensemble MLmethods could provide significant improvements in skin lesion classifications.
Keywords
Skin Cancer Detection, Machine Learning, Deep Learning, Feature Selection, Data Cleaning
References
Obaid, Abbas Luaibi, Nabeel Mahdy Haddad, and Mustafa Sabah Taha. "DL-SCDDS: Accurate Skin Cancer Detection and Diagnosis Scheme Based on an Improved Convolutional Neural Networks Model." International Human-Centered Technology Conference. Cham: Springer Nature Switzerland, 2024.
Haque, Shafiul, et al. "Skin cancer detection using DLapproaches." Cancer Biotherapy and Radiopharmaceuticals 40.5 (2025): 301-312.
Furriel, Brunna CRS, et al. "Artificial intelligence for skin cancer detection and classification for clinical environment: a systematic review." Frontiers in medicine 10 (2024): 1305954.
Hermosilla, Pamela, et al. "Skin cancer detection and classification using neural network algorithms: A systematic review." Diagnostics 14.4 (2024): 454.
Kaur, Ranpreet, Hamid GholamHosseini, and Maria Lindén. "Advanced DLmodels for melanoma diagnosis in computer-aided skin cancer detection." Sensors 25.3 (2025): 594.
Roky, Amdad Hossain, et al. "Overview of skin cancer types and prevalence rates across continents." Cancer pathogenesis and therapy 3.02 (2025): 89-100.
Imran, Azhar, et al. "Skin cancer detection using combined decision of deep learners." ieee Access 10 (2022): 118198-118212.
Walker, Bruce N., et al. "Skin cancer detection in diverse skin tones by MLcombining audio and visual convolutional neural networks." Oncology 103.5 (2025): 413-420.
Walker, Bruce N., et al. "Skin cancer detection in diverse skin tones by MLcombining audio and visual convolutional neural networks." Oncology 103.5 (2025): 413-420.
Pacal, Ishak, et al. "A novel CNN-ViT-based DLmodel for early skin cancer diagnosis." Biomedical Signal Processing and Control 104 (2025): 107627.
Kong, Lingping, et al. "Enhancing skin cancer detection through category representation and fusion of pre-trained models." Information Fusion 124 (2025): 103369.
Berry, Elizabeth, et al. "Molecular Imaging in Early Skin Cancer Detection: Advances, Limitations, and Future Directions." Technology in Cancer Research & Treatment 24 (2025): 15330338251410073.
Nawaz, Khadija, et al. "Skin cancer detection using dermoscopic images with convolutional neural network." Scientific Reports 15.1 (2025): 7252.
Nazari, Sana, and Rafael Garcia. "Automatic skin cancer detection using clinical images: a comprehensive review." Life 13.11 (2023): 2123.
Jabbar, Noor Kareem, Majn Naderan, and Mustafa Sabah Taha. "HybridIoMT: A Dual-Phase MLFramework for Robust Cybersecurity in Internet of Medical Things." International Journal of Intelligent Engineering & Systems 18.4 (2025).
Asraa, Safaa Ahmed, et al. "An Accurate Model for Text Document Classification Using MLTechniques." Ingenierie des Systemes d'Information 30.4 (2025): 913.
Schnawa, Salam Abdulzahra, Mahnaz Rafie, and Mustafa Sabah Taha. "DAE-DBN: An effective lung cancer detection model based on hybrid DLapproaches." International Conference of Reliable Information and Communication Technology. Cham: Springer Nature Switzerland, 2023.
Ogundokun, Roseline Oluwaseun, et al. "Enhancing skin cancer detection and classification in dermoscopic images through concatenated MobileNetV2 and xception models." Bioengineering 10.8 (2023): 979.
Sideek, Shirin Muataz Mohammed, et al. "An Improved Anomaly-based Intrusion Detection System for IoT Applications using MLMethods." Pertanika Journal of Science & Technology 34.1 (2026).
Ahmed, Attallah Salih, Israa Nasir Abood, and Mustafa Sabah Taha. "Adaptive Multi-objective Optimization for Obstacle-aware Wireless Sensor Network Deployment: A Comparative Analysis of State-of-the-Art Algorithms." International Journal of Intelligent Engineering & Systems 19.2 (2026).
Ismael, Bahaa Muneer, et al. "Non-dominated sorting genetic algorithm for channel assignment in multiple radio interfaces with multiple channels." AIP Conference Proceedings. Vol. 3393. No. 1. AIP Publishing LLC, 2026.
Abood, Israa Nasir, Attallah Salih Ahmed, and Mustafa Sabah Taha. "An Efficient Genetic Algorithm-based Approach for Association Rule Hiding in Privacy-preserving Data Mining: A Parallel Processing Framework." International Journal of Intelligent Engineering & Systems 18.11 (2025).
Haref, Qasim Mahdi, et al. "Categorization of spatial domain techniques in image steganography: a revisit." J Adv Res Dyn Control Syst 10: 1538-1551.
Ismael, Bahaa Muneer, et al. "Multi-Agent Reinforcement Learning for User-Router Assignment in Multi-Radio Multi-Channel Wireless Mesh Networks." International Journal of Intelligent Engineering & Systems 18.8 (2025).
Velaga, NandaKiran, et al. "Skin cancer detection using the HAM10000 dataset: A comparative study of MLmodels." 2023 Global conference on information technologies and communications (GCITC). IEEE, 2023.
Singh, Jagandeep, Jasminder Kaur Sandhu, and Yogesh Kumar. "An analysis of detection and diagnosis of different classes of skin diseases using artificial intelligence-based learning approaches with hyper parameters." Archives of Computational Methods in Engineering 31.2 (2024): 1051-1078.
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