Medical Science
| Open Access |
DOI: Changes in Thymus and Spleen Morphology Under Stress in Early and Adult Generations
Normuradov Aliyor Doniyor o’g’li , Assistant, Tashkent State Medical University, Tashkent, Uzbekistan Axmedova Sayyora Muhamadovna , Professor, Tashkent State Medical University, Tashkent, UzbekistanAbstract
The article studied the morphological and morphometric characteristics of the thymus organ of 3- and 21-day old offspring born from mother rats exposed to chronic stress and compared them with offspring in the control group, and developed an appropriate assessment criterion. The expected results showed that the thymus of the offspring in the experimental group showed profound and significant morphological changes compared to those in the control group.
Keywords
Thymus, spleen, stress
References
Cheong JN, Cuffe JS, Jefferies AJ, Anevska K, Moritz KM, Wlodek ME. Sex-Specific Metabolic Outcomes in Offspring of Female Rats Born Small or Exposed to Stress During Pregnancy. Endocrinology. 2016 Nov;157(11):4104-4120.
Chou MY, Huang LT, Tain YL, Kuo HC, Tiao MM, Sheen JM, Chen CC, Hung PL, Hsieh KS, Yu HR. Age-Dependent Effects of Prenatal Dexamethasone Exposure on Immune Responses in Male Rats. Tohoku J Exp Med. 2017 Mar;241(3):225-237.
Ebaid HM, Elgawish RA, Abdelrazek HM, Gaffer G, Tag HM. Prenatal Exposure to Soy Isoflavones Altered the Immunological Parameters in Female Rats. Int J Toxicol. 2016 May;35(3):274-83.
Gotardo A. T. et al. Maternal feed restriction during pregnancy in Wistar rats: Evaluation of offspring using classical and immunoteratology protocols //Human & Experimental Toxicology. 2017; 36(6):603-615.
Hancı H, Türedi S, Topal Z, Mercantepe T, Bozkurt I, Kaya H, Ersöz Ş, Ünal B, Odacı E. Can prenatal exposure to a 900 MHz electromagnetic field affect the morphology of the spleen and thymus, and alter biomarkers of oxidative damage in 21-day-old male rats? Biotech Histochem. 2015;90(7):535-43.
Hussain A, Kumar S, Kaul G. Postnatal distribution of ZnO nanoparticles to the breast milk through oral route and their risk assessment for breastfed rat offsprings. Hum Exp Toxicol. 2020 Oct;39(10):1318-1332.
Khavinson VK, Linkova NS, Chalisova NI, Ivko OM. The Use of Thymalin for Immunocorrection and Molecular Aspects of Biological Activity. Biol Bull Rev. 2021;11(4):377–82.
Lalić IM, Miljković M, Labudović-Borović M, Milić N, Milićević NM. Postnatal development of metallophilic macrophages in the rat thymus. Anat Histol Embryol. 2020 Jul;49(4):433-439.
Download and View Statistics
Copyright License
Copyright (c) 2026 Normuradov Aliyor Doniyor o’g’li, Axmedova Sayyora Muhamadovna
This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors retain the copyright of their manuscripts, and all Open Access articles are disseminated under the terms of the Creative Commons Attribution License 4.0 (CC-BY), which licenses unrestricted use, distribution, and reproduction in any medium, provided that the original work is appropriately cited. The use of general descriptive names, trade names, trademarks, and so forth in this publication, even if not specifically identified, does not imply that these names are not protected by the relevant laws and regulations.