Medical Sciences
OPEN ACCESS
Effects Of F-18 On KCL And Phenylephrine - Induced Contractions Of Rat Aorta
DOI
Crossref DOI
10.37547/TAJMSPR/Volume03Issue06-16
tajmspr
2021
VOL. 3
/ NO. 06
JUNE
RESEARCH OVERVIEW
Abstract
The mechanism of action of the alkaloid 1-(2´-bromine-4´,5´-dimethoxyphenyl) - 6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline (F-18) on the functional activity of smooth muscle cells of the rat aorta was studied. Isometric contraction activity was recorded using a Grass FT – 03 (Grass Instrument, USA) mechanotron. The relaxant effect of the F-18 alkaloid was found to be associated with blockade of Ca2 + (IP3R) channels in the SR, along with voltage- dependent and receptor-operated Ca2+channels in the aorta smooth muscle cell plasmalemma.
RESEARCH TOPICS
Keywords
Rat aorta
vascular smooth muscle cells
vasorelaxation
Ca2 -channel
Downloads
Download data is not yet available.
SOURCES & SCHOLARSHIP
References
- Braunwald, E. (2015). The war against heart failure: the Lancet lecture. The Lancet, 385(9970), 812-824.
- Catterall, W. A. (2000). Structure and regulation of voltage-gated Ca2+ channels. Annual review of cell and developmental biology, 16(1), 521-555.
- Catterall, W. A. (2000). Structure and regulation of voltage-gated Ca2+ channels. Annual review of cell and developmental biology, 16(1), 521-555.
- Esimbetov A.T., Zaripov A.A., Omanturdiev S.Z., Sultankhodjaev М.N., Usmanov P.B. (2020). Vasorelaxant effect of the alkaloid 1–0–benzoylnappeline on isolated rat thoracic aorta. International journal of agriculture, environment and bioresearch. №5. P.146-156.
- Gao, B., Sekido, Y., Maximov, A., Saad, M., Forgacs, E., Latif, F., ... & Minna, J. D. (2000). Functional properties of a new voltage-dependent calcium channel α2δ auxiliary subunit gene (CACNA2D2). Journal of Biological Chemistry, 275(16), 12237-12242.
- Harrison, D. G., & Gongora, M. C. (2009). Oxidative stress and hypertension. Medical Clinics, 93(3), 621-635.
- Kearney, P. M., Whelton, M., Reynolds, K., Muntner, P., Whelton, P. K., & He, J. (2005). Global burden of hypertension: analysis of worldwide data. The lancet, 365(9455), 217-223.
- Lee, K., Park, G., Ham, I., Yang, G., Lee, M., Bu, Y., ... & Choi, H. Y. (2013). Vasorelaxant effect of Osterici radix ethanol extract on rat aortic rings. Evidence-Based Complementary and Alternative Medicine, 2013.
- Li, X., Chen, G. P., Li, L., Wang, K. J., Zhang, B. Q., & Hu, S. J. (2010). Dual effects of sodium aescinate on vascular tension in rat thoracic aorta. Microvascular research, 79(1), 63-69.
- Lifton, R. P., Gharavi, A. G., & Geller, D. S. (2001). Molecular mechanisms of human hypertension. Cell, 104(4), 545-556.
- Nishimura, K., Ota, M., & Ito, K. (1991). Existence of two components in the tonic contraction of rat aorta mediated by α1‐adrenoceptor activation. British journal of pharmacology, 102(1), 215-221.
- Vandier, C., Le Guennec, J. Y., & Bedfer, G. (2002). What are the signaling pathways used by norepinephrine to contract the artery? A demonstration using guinea pig aortic ring segments. Advances in physiology education, 26(3), 195-203.
- Waeber, B. (2002). Fixed low-dose combination therapy for hypertension. Current hypertension reports, 4(4), 298-306.
- Webb, R. C. (2003). Smooth muscle contraction and relaxation. Advances in physiology education, 27(4), 201-206.
- Wier, W. G., & Morgan, K. G. (2003). α 1-Adrenergic signaling mechanisms in contraction of resistance arteries. Reviews of physiology, biochemistry and pharmacology, 91-139.
- Wray, S., & Burdyga, T. (2010). Sarcoplasmic reticulum function in smooth muscle. Physiological reviews, 90(1), 113-178.
- Zambon, A., Arfe, A., Corrao, G., & Zanchetti, A. (2014). Relationships of different types of event to cardiovascular death in trials of antihypertensive treatment: an aid to definition of total cardiovascular disease risk in hypertension. Journal of hypertension, 32(3), 495-508.