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АNALYSIS OF THE ROLE OF FOLATE CYCLE GENES IN THE PATHOGENESIS OF ROSACEA

Agzamkhodzhaeva S.S.
Tashkent State Dental Institute, Uzbekistan
Azizov B.S.
Tashkent State Dental Institute, Uzbekistan
Ayupova Sh.T.
Tashkent State Dental Institute, Uzbekistan
Dyo K.G.
Institute Of Immunology And Human Genomics Under The Academy Of Sciences Of The Republic Of Uzbekistan
Khegay T.R.
Institute Of Immunology And Human Genomics Under The Academy Of Sciences Of The Republic Of Uzbekistan
DOI Crossref DOI 10.37547/TAJMSPR/Volume05Issue03-04
tajmspr 2023
VOL. 5 / NO. 03 MARCH
FULL TEXT PP. 16-22
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VOLUME 5
ISSUE 03
YEAR 2023
PAGES 16-22
RESEARCH OVERVIEW

Abstract

The polymorphism of the genes of the folate cycle was studied. The study identified genes that are presumably involved in the occurrence and development of rosacea, as well as affecting the severity of the disease. Unfavorable variants of the folate metabolism genes: MTHFR: 1298 A>C rs1801131, MTHFR: 677C>T rs1801133. An increase in the level of homocysteine in the blood of patients with rosacea turned out to be significant. The identified loci provide specificity of inflammatory mechanisms in rosacea, and identify potential pathways for therapeutic intervention.

RESEARCH TOPICS

Keywords

Rosacea SNP folate

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