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Toxicity And Anti-Arrhythmic Activity 1- (4-Dimethylaminophenyl Dimethylaminophenyl) -6, 7-Dimethoxy-1, 2, 3, 4 Tetrahydroisoquinoline

RejepovJumadilla,
Candidate Of Medical Sciences, Institute Of Plant Chemistry Named After Academician S.Yu. Junusov Of The Academy Of Sciences, Tashkent City, Uzbekistan
Rakhmanova Hilola
Phd 1-Course, Institute Of Plant Chemistry Named After Academician S.Yu. Junusov Of The Academy Of Sciences, Tashkent City, Uzbekistan
Azamatov Aziz
Junior Science Of Research Institute Of Plant Chemistry Named After Academician S.Yu. Junusov Of The Academy Of Sciences, Tashkent City, Uzbekistan
DOI Crossref DOI 10.37547/TAJMSPR/Volume02Issue07-17
tajmspr 2020
VOL. 2 / NO. 07 JULY
FULL TEXT PP. 130-133
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VOLUME 2
ISSUE 07
YEAR 2020
PAGES 130-133
RESEARCH OVERVIEW

Abstract

The effect of 1 - (- 4-dimethylaminophenyl) -6,7-dimethoxy-1,2,3,4-
tetrahydroisoquinoloin hydrochloride (conditionally –F-24) on antiarrhythmicactivity in
simulating calcium chloride arrhythmia, as well as acute toxicity in experiments, was
studied on white out bred rats with the intravenous route of administration. It was found
that the drug F-24 has a pronounced ant arrhythmic effect. The average effective (ED50)
ant arrhythmic dose is 4.8 mg/kg, the ant arrhythmic index is 20.3, which is significantly
more than the comparison drugs verapamil and lidocaine.

RESEARCH TOPICS

Keywords

alkaloid ant arrhythmic activity

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