Shatkriya Kala in Ayurveda: A Comprehensive Framework for Understanding the Stages and Mechanisms of Disease Pathogenesis
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The Ayurvedic concept of Shatkriya Kala represents a systematic framework for understanding the sequential development, progression, and clinical manifestation of diseases. Rooted in classical Ayurvedic principles, this concept describes six progressive stages of disease evolution: Sanchaya (accumulation), Prakopa (aggravation), Prasara (dissemination), Sthana-Samshraya (localization), Vyakti (clinical manifestation), and Bheda (differentiation or complication). Unlike disease models that primarily emphasize the identification of established clinical symptoms, Shatkriya Kala provides a stage-oriented perspective in which pathological changes are recognized as progressive processes influenced by Dosha, Dhatu, Agni, and Srotas. The present review aims to examine the theoretical foundation, functional organization, and clinical significance of Shatkriya Kala as an integrated model of Ayurvedic etiopathogenesis. A conceptual narrative review approach was adopted through examination and synthesis of the thirteen references supplied, including classical Ayurvedic texts, foundational publications, and contemporary discussions of disease progression. The analysis identifies the six stages as an interconnected pathological sequence that provides a theoretical basis for understanding early disturbances, disease localization, clinical presentation, and subsequent complications. The framework also emphasizes the importance of early recognition and stage-specific therapeutic planning. However, its contemporary application requires clearer operational definitions, standardized clinical indicators, and systematic validation. Shatkriya Kala therefore offers a valuable conceptual architecture for studying Ayurvedic pathogenesis and developing structured approaches to preventive and individualized healthcare.