The socio-economic transformation of Uzbekistan during the period 2022–2026 represents a critical phase in the nation’s transition toward sustainable development, modernization, and global integration. This study develops a systems-based analytical model to evaluate the structural dynamics, policy mechanisms, and socio-economic outcomes associated with Uzbekistan’s development strategy. Drawing upon historical, economic, and cultural references, the research integrates traditional economic practices with contemporary reform frameworks to construct a multidimensional transformation model. The study employs a qualitative systems analysis approach, synthesizing historical data, field observations, and policy-driven economic structures to examine interdependencies between agriculture, crafts, industrial growth, and socio-cultural evolution. Findings indicate that sustainable transformation in Uzbekistan is contingent upon the harmonization of traditional economic systems with modern institutional reforms, particularly in rural economies such as the Kashkadarya oasis. The research identifies critical drivers, including agricultural modernization, cultural-economic integration, and policy-based governance reforms. However, structural limitations such as regional disparities and institutional inefficiencies persist. The study contributes to the theoretical discourse on transition economies by proposing a hybrid socio-economic transformation model that integrates historical continuity with innovation-driven development strategies.