Articles
| Open Access |
DOI: Influence Of Galangin On Respiration And Oxidative Phosphorylation Of Rat Liver Mitochondria
Yusupova Umida , Department of Human and Animal Physiology, PhD, National University of Uzbekistan named after Mirzo Ulugbek, Tashkent, Uzbekistan Mamatova Zulaykho , Head of Department of Human and Animal Physiology, PhD assistant professor, National University of Uzbekistan named after Mirzo Ulugbek, Tashkent, Uzbekistan Dzhabbarova Gulchehra , Human and Animal Physiology, PhD assistant professor, National University of Uzbekistan named after Mirzo Ulugbek, Tashkent, Uzbekistan Tukhtaeva Feruza , , Physiology of humans and animals, intern, National University of Uzbekistan named after Mirzo Ulugbek, Tashkent, Uzbekistan Almatov Karim , Department of Human and Animal Physiology, Professor, National University of Uzbekistan named after Mirzo Ulugbek, Tashkent, UzbekistanAbstract
The influence of galangin on the respiration and oxidative phosphorylation of rat liver
mitochondria is studied in vitro conditions. It was found that galangin increases a glutamate oxidation
in V2 and V4 states, but it does not affect on the rate of mitochondrial phosphorylating respiration (V3).
The respiratory quotient value by Chance dose-dependently decreases. High concentration of galangin
raises the ADP:O quotient. At the same time, in low concentration the galangin does not influence on
the succinate oxidations, however, with increasing of its concentration the mitochondrial respiration
by succinate increases simultaneously. Thus the ADP/O quotient decreases significantly and the
respiratory quotient value by Chance, on the contrary, decreases slightly.
Keywords
galangin, respiration
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