The article is devoted to the theoretical and applied rationale for a comprehensive strategy to prevent cross-contamination during the cleaning of general-purpose medical offices. The relevance of the study is determined by heightened requirements for infection safety in the ambulatory sector, particularly against the backdrop of the post-pandemic agenda. The scientific novelty is formulated as the integration of contemporary, evidence-based cleaning regulations with environmentally safe agents and the authors’ results on optimizing organizational processes. The paper systematizes the key pathways of pathogen transmission in the medical environment and examines current approaches to interrupting them, including the use of microfiber, color coding of equipment, and methods for verifying cleanliness. Special emphasis is placed on the role of staff training and the ergonomics of operations as determinants of cleaning quality. The aim of the study is to propose a standardized cleaning model that minimizes cross-contamination risks while simultaneously enhancing operational efficiency and the safety of patients and staff. The methodological toolkit includes an analytical review of the scientific literature and comparative analysis. Sources on infection control, modern cleaning materials, and sustainable practices in healthcare are analyzed. The conclusion demonstrates the effectiveness of the proposed model, confirmed by the authors’ data, and shows its applicability across a wide range of ambulatory facilities. The materials of the article are addressed to managers of medical organizations, infection control specialists, and cleaning companies.

cross-contamination, infection control, cleaning of medical offices, surface disinfection, color coding

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