Medical Science
OPEN ACCESS
Neurogenic Mechanisms, Takotsubo Syndrome, And Prevention of Stress-Induced Cardiovascular Diseases
DOI
Crossref DOI
10.37547/tajmspr/Volume08Issue04-19
tajmspr
2026
VOL. 8
/ NO. 04
APRIL
RESEARCH OVERVIEW
Abstract
This article systematizes the neurogenic and psychophysiological mechanisms of stress-induced cardiovascular diseases, including Takotsubo syndrome, as well as psychological risk factors and preventive directions. It shows that catecholamine release, inflammation, endothelial dysfunction, personality traits, and a lack of social support form a unified pathogenetic framework that should be addressed by psychocardiological and rehabilitation interventions.
RESEARCH TOPICS
Keywords
Stress
catecholamines
Takotsubo syndrome
Downloads
Download data is not yet available.
SOURCES & SCHOLARSHIP
References
- Белялов Ф. И., Вельтищев Д. Ю., Волель Б. А., Гарганеева Н. П., Копылов Ф. Ю., Ларева Н. В. и др. Психические расстройства у пациентов с сердечно-сосудистыми заболеваниями. Консенсус рабочих групп Российского кардиологического общества и Российского общества психиатров // Кардиология. 2025. Т. 65, № 6. С. 54–73. https://therapy.irkutsk.ru/ispm/psomatic_card2c11.pdf
- McKenzie A., Bargout R. Takotsubo Syndrome in 2025: Evolving Concepts in Pathophysiology, Diagnosis, and Long-Term Management // Journal of Clinical Medicine. 2026. Vol. 15, No. 1. Art. 197. https://www.researchgate.net/publication/399138036_Takotsubo_Syndrome_in_2025_Evolving_Concepts_in_Pathophysiology_Diagnosis_and_Long-Term_Management
- Bacca C. F., Stephan B., Gomez V., Gioli-Pereira L. и др. Use of beta-blockers and in-hospital mortality in patients with Takotsubo cardiomyopathy: systematic review and meta-analysis // Open Heart. 2025. Vol. 12, No. 2. e003762. https://pmc.ncbi.nlm.nih.gov/articles/PMC12581082/
- Larionov K., Petrova E., Demirbuga N., Werth O., Breitner M. H., Gebhardt P., Caldarone F., Duncker D., Westhoff-Bleck M., Sensenhauser A., Maxrath N., Marschollek M., Kahl K. G., Heitland I. Improving mental well-being in psychocardiology—a feasibility trial for a non-blended web application as a brief metacognitive-based intervention in cardiovascular disease patients // Frontiers in Psychiatry. 2023. Vol. 14. Art. 1138475. https://pmc.ncbi.nlm.nih.gov/articles/PMC10568139/
- Bueno H., Deaton C., Farrero M., Forsyth F., Braunschweig F., Buccheri S. и др. 2025 ESC Clinical Consensus Statement on mental health and cardiovascular disease: developed under the auspices of the ESC Clinical Practice Guidelines Committee // European Heart Journal. 2025. Vol. 46, No. 41. P. 4156–4225. https://www.escardio.org/guidelines/clinical-practice-guidelines/all-esc-practice-guidelines/mental-health-and-cvd/
- Ghadri J.-R., Wittstein I. S., Prasad A., Sharkey S., Dote K., Akashi Y. J., Cammann V. L. и др. International Expert Consensus Document on Takotsubo Syndrome (Part I): Clinical Characteristics, Diagnostic Criteria, and Pathophysiology // European Heart Journal. https://oup.silverchair-cdn.com/article-minimal/5025412
- Madaudo C., Kurdi H., Ielapi J. и др. The Role of Inflammation in Takotsubo Syndrome: From Pathogenic Pathways To Imaging Insights and Therapeutic Perspectives // Current Cardiology Reports. 2026. Vol. 28, No. 1. Art. 20. https://pmc.ncbi.nlm.nih.gov/articles/PMC12868080/
- Chu B., Marwaha K., Sanvictores T., Awosika A. O., Ayers D. Physiology, Stress Reaction // StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2026 Jan-. https://www.ncbi.nlm.nih.gov/books/NBK541120/
- Rezkalla S. H., Kloner R. A. Stress and Acute Coronary Syndrome // Cardiology Research. 2025. Vol. 16, No. 6. P. 467–474. https://pmc.ncbi.nlm.nih.gov/articles/PMC12758085/
- Ebong I. A., Quesada O. и др.; American College of Cardiology Cardiovascular Disease in Women Committee. The Role of Psychosocial Stress on Cardiovascular Disease in Women: JACC State-of-the-Art Review // Journal of the American College of Cardiology. 2024. Vol. 84, No. 3. P. 298–314. https://pmc.ncbi.nlm.nih.gov/articles/PMC11328148/
- Khalid N., Shams P., Shlofmitz E., Chhabra L. Pathophysiology of Takotsubo Syndrome // StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2026 Jan-. https://www.ncbi.nlm.nih.gov/books/NBK538160/
- Kupper N., Denollet J. Type D Personality as a Risk Factor in Coronary Heart Disease: a Review of Current Evidence // Current Cardiology Reports. 2018. Vol. 20, No. 11. Art. 104. https://pmc.ncbi.nlm.nih.gov/articles/PMC6153564/
- Carola V., Vincenzo C., Di Vincenzo G., Morale C., Cecchi V., Nicolais G. Psychological risk factors and cardiovascular disease // Frontiers in Psychology. 2024. Vol. 15. Art. 1419731. https://pubmed.ncbi.nlm.nih.gov/39403242/
- Armon D. B., Buhayer A., Miteva K., Meinlschmidt G. и др. Depression and cardiovascular disease: mind the gap in the guidelines // European Heart Journal. 2025. Vol. 46, No. 41. P. 4226. https://pmc.ncbi.nlm.nih.gov/articles/PMC12579981/
- Marino F., Failla C., Carrozza C., Ciminata M., Chilà P., Minutoli R., Genovese S., Puglisi A., Arnao A. A., Tartarisco G. и др. Mindfulness-Based Interventions for Physical and Psychological Wellbeing in Cardiovascular Diseases: A Systematic Review and Meta-Analysis // Brain Sciences. 2021. Vol. 11, No. 6. Art. 727. https://pmc.ncbi.nlm.nih.gov/articles/PMC8227381/
- Rees K., Bennett P., West R., Davey Smith G., Ebrahim S. Psychological interventions for coronary heart disease // Cochrane Database of Systematic Reviews. 2004. No. 2. CD002902. https://pmc.ncbi.nlm.nih.gov/articles/PMC4170898/