Neurogenic Mechanisms, Takotsubo Syndrome, And Prevention of Stress-Induced Cardiovascular Diseases
Azamatjonov Akmaljon , Farhodjonovich, 2nd-Year Student of the 2nd Faculty of Medicine, Tashkent State Medical University, Uzbekistan Ganiyev Samandar Fazliddinovich , 2nd-Year Student of the 2nd Faculty of Medicine, Tashkent State Medical University, Uzbekistan Khusanov Ravshan Akhrorovich , Cardiologist, Highly Qualified Cardio-Reanimatologist, Phd, Associate Professor at The Department of Clinical Subjects, Tashkent International University Of KIMYO, Uzbekistan Baymuratova Dilfuza Kutlimuratovna , 2nd-Year Student of the 2nd Faculty of Medicine, Tashkent State Medical University, Uzbekistan Khujakhonova Maftuna Tokhirovna , Lecturer of the Department of Pedagogy and Psychology, Tashkent State Medical University, UzbekistanAbstract
This article systematizes the neurogenic and psychophysiological mechanisms of stress-induced cardiovascular diseases, including Takotsubo syndrome, as well as psychological risk factors and preventive directions. It shows that catecholamine release, inflammation, endothelial dysfunction, personality traits, and a lack of social support form a unified pathogenetic framework that should be addressed by psychocardiological and rehabilitation interventions.
Keywords
Stress, catecholamines, Takotsubo syndrome
References
Белялов Ф. И., Вельтищев Д. Ю., Волель Б. А., Гарганеева Н. П., Копылов Ф. Ю., Ларева Н. В. и др. Психические расстройства у пациентов с сердечно-сосудистыми заболеваниями. Консенсус рабочих групп Российского кардиологического общества и Российского общества психиатров // Кардиология. 2025. Т. 65, № 6. С. 54–73. https://therapy.irkutsk.ru/ispm/psomatic_card2c11.pdf
McKenzie A., Bargout R. Takotsubo Syndrome in 2025: Evolving Concepts in Pathophysiology, Diagnosis, and Long-Term Management // Journal of Clinical Medicine. 2026. Vol. 15, No. 1. Art. 197. https://www.researchgate.net/publication/399138036_Takotsubo_Syndrome_in_2025_Evolving_Concepts_in_Pathophysiology_Diagnosis_and_Long-Term_Management
Bacca C. F., Stephan B., Gomez V., Gioli-Pereira L. и др. Use of beta-blockers and in-hospital mortality in patients with Takotsubo cardiomyopathy: systematic review and meta-analysis // Open Heart. 2025. Vol. 12, No. 2. e003762. https://pmc.ncbi.nlm.nih.gov/articles/PMC12581082/
Larionov K., Petrova E., Demirbuga N., Werth O., Breitner M. H., Gebhardt P., Caldarone F., Duncker D., Westhoff-Bleck M., Sensenhauser A., Maxrath N., Marschollek M., Kahl K. G., Heitland I. Improving mental well-being in psychocardiology—a feasibility trial for a non-blended web application as a brief metacognitive-based intervention in cardiovascular disease patients // Frontiers in Psychiatry. 2023. Vol. 14. Art. 1138475. https://pmc.ncbi.nlm.nih.gov/articles/PMC10568139/
Bueno H., Deaton C., Farrero M., Forsyth F., Braunschweig F., Buccheri S. и др. 2025 ESC Clinical Consensus Statement on mental health and cardiovascular disease: developed under the auspices of the ESC Clinical Practice Guidelines Committee // European Heart Journal. 2025. Vol. 46, No. 41. P. 4156–4225. https://www.escardio.org/guidelines/clinical-practice-guidelines/all-esc-practice-guidelines/mental-health-and-cvd/
Ghadri J.-R., Wittstein I. S., Prasad A., Sharkey S., Dote K., Akashi Y. J., Cammann V. L. и др. International Expert Consensus Document on Takotsubo Syndrome (Part I): Clinical Characteristics, Diagnostic Criteria, and Pathophysiology // European Heart Journal. https://oup.silverchair-cdn.com/article-minimal/5025412
Madaudo C., Kurdi H., Ielapi J. и др. The Role of Inflammation in Takotsubo Syndrome: From Pathogenic Pathways To Imaging Insights and Therapeutic Perspectives // Current Cardiology Reports. 2026. Vol. 28, No. 1. Art. 20. https://pmc.ncbi.nlm.nih.gov/articles/PMC12868080/
Chu B., Marwaha K., Sanvictores T., Awosika A. O., Ayers D. Physiology, Stress Reaction // StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2026 Jan-. https://www.ncbi.nlm.nih.gov/books/NBK541120/
Rezkalla S. H., Kloner R. A. Stress and Acute Coronary Syndrome // Cardiology Research. 2025. Vol. 16, No. 6. P. 467–474. https://pmc.ncbi.nlm.nih.gov/articles/PMC12758085/
Ebong I. A., Quesada O. и др.; American College of Cardiology Cardiovascular Disease in Women Committee. The Role of Psychosocial Stress on Cardiovascular Disease in Women: JACC State-of-the-Art Review // Journal of the American College of Cardiology. 2024. Vol. 84, No. 3. P. 298–314. https://pmc.ncbi.nlm.nih.gov/articles/PMC11328148/
Khalid N., Shams P., Shlofmitz E., Chhabra L. Pathophysiology of Takotsubo Syndrome // StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2026 Jan-. https://www.ncbi.nlm.nih.gov/books/NBK538160/
Kupper N., Denollet J. Type D Personality as a Risk Factor in Coronary Heart Disease: a Review of Current Evidence // Current Cardiology Reports. 2018. Vol. 20, No. 11. Art. 104. https://pmc.ncbi.nlm.nih.gov/articles/PMC6153564/
Carola V., Vincenzo C., Di Vincenzo G., Morale C., Cecchi V., Nicolais G. Psychological risk factors and cardiovascular disease // Frontiers in Psychology. 2024. Vol. 15. Art. 1419731. https://pubmed.ncbi.nlm.nih.gov/39403242/
Armon D. B., Buhayer A., Miteva K., Meinlschmidt G. и др. Depression and cardiovascular disease: mind the gap in the guidelines // European Heart Journal. 2025. Vol. 46, No. 41. P. 4226. https://pmc.ncbi.nlm.nih.gov/articles/PMC12579981/
Marino F., Failla C., Carrozza C., Ciminata M., Chilà P., Minutoli R., Genovese S., Puglisi A., Arnao A. A., Tartarisco G. и др. Mindfulness-Based Interventions for Physical and Psychological Wellbeing in Cardiovascular Diseases: A Systematic Review and Meta-Analysis // Brain Sciences. 2021. Vol. 11, No. 6. Art. 727. https://pmc.ncbi.nlm.nih.gov/articles/PMC8227381/
Rees K., Bennett P., West R., Davey Smith G., Ebrahim S. Psychological interventions for coronary heart disease // Cochrane Database of Systematic Reviews. 2004. No. 2. CD002902. https://pmc.ncbi.nlm.nih.gov/articles/PMC4170898/
Download and View Statistics
Copyright License
Copyright (c) 2026 Azamatjonov Akmaljon, Ganiyev Samandar Fazliddinovich, Khusanov Ravshan Akhrorovich, Baymuratova Dilfuza Kutlimuratovna, Khujakhonova Maftuna Tokhirovna

This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors retain the copyright of their manuscripts, and all Open Access articles are disseminated under the terms of the Creative Commons Attribution License 4.0 (CC-BY), which licenses unrestricted use, distribution, and reproduction in any medium, provided that the original work is appropriately cited. The use of general descriptive names, trade names, trademarks, and so forth in this publication, even if not specifically identified, does not imply that these names are not protected by the relevant laws and regulations.

Medical Science
| Open Access |
DOI: