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Medical Science OPEN ACCESS

Acute Toxicity and Antitoxic Effect of Compositions of Cytisine N-Alkyl (Aryl) Derivatives with Succinic Acid

Latipova Shaxla Bekdurdiyevna
Assistant of the Department of Pharmacology and Clinical Pharmacology, Urgench state medical university, Urgench, Uzbekistan
Azamatov Azizbek Azamat o‘g‘li
PhD, Senior researcher at the Department of Pharmacology and Toxicology of the Institute of the Chemistry of Plant Substances, Academy of Sciences of the Republic of Uzbekistan
Tursunkhodzhaeva Firuza Muratovna
DSc, professor, Head of the Department of Pharmacology and Toxicology of the Institute of Chemistry of Plant Substances, Academy of Sciences of the Republic of Uzbekistan
Aytmuratova Urkhiya Kallibekovna
PhD student, Department of Pharmacology and Toxicology, the Institute of the Chemistry of Plant Substances, Academy of Sciences of the Republic of Uzbekistan
DOI Crossref DOI 10.37547/tajmspr/Volume08Issue02-31
tajmspr 2026
VOL. 8 / NO. 2 FEBRUARY
FULL TEXT PP. 207-210
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VOLUME 8
ISSUE 2
YEAR 2026
PAGES 207-210
RESEARCH OVERVIEW

Abstract

In the article, the acute toxicity, resorptive effects, and antitoxic activity of N-alkyl (aryl) derivatives of cytisine and their compositions with succinic acid were studied in experimental animals using models of alcohol- and hypnotic-induced intoxication. The results demonstrated that these compositions possess relatively low acute toxicity and exhibit antitoxic effects under conditions of narcotic intoxication by reducing the duration of sleep.

RESEARCH TOPICS

Keywords

Cytisine derivatives succinic acid antitoxic effect

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