Medical Science
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DOI: Acute Toxicity and Antitoxic Effect of Compositions of Cytisine N-Alkyl (Aryl) Derivatives with Succinic Acid
Latipova Shaxla Bekdurdiyevna , Assistant of the Department of Pharmacology and Clinical Pharmacology, Urgench state medical university, Urgench, Uzbekistan Azamatov Azizbek Azamat o‘g‘li , PhD, Senior researcher at the Department of Pharmacology and Toxicology of the Institute of the Chemistry of Plant Substances, Academy of Sciences of the Republic of Uzbekistan Tursunkhodzhaeva Firuza Muratovna , DSc, professor, Head of the Department of Pharmacology and Toxicology of the Institute of Chemistry of Plant Substances, Academy of Sciences of the Republic of Uzbekistan Aytmuratova Urkhiya Kallibekovna , PhD student, Department of Pharmacology and Toxicology, the Institute of the Chemistry of Plant Substances, Academy of Sciences of the Republic of UzbekistanAbstract
In the article, the acute toxicity, resorptive effects, and antitoxic activity of N-alkyl (aryl) derivatives of cytisine and their compositions with succinic acid were studied in experimental animals using models of alcohol- and hypnotic-induced intoxication. The results demonstrated that these compositions possess relatively low acute toxicity and exhibit antitoxic effects under conditions of narcotic intoxication by reducing the duration of sleep.
Keywords
Cytisine derivatives, succinic acid, antitoxic effect
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Copyright (c) 2026 Latipova Shaxla Bekdurdiyevna, Azamatov Azizbek Azamat o‘g‘li, Tursunkhodzhaeva Firuza Muratovna, Aytmuratova Urkhiya Kallibekovna
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