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Medical Science OPEN ACCESS

Acute Pancreatitis And Cationic Trypsinogen Gene Polymorphism In The Uzbek Population

Ismailov Uktam Safaevich
Department of Surgical Diseases No. 1, Tashkent State Medical University, Uzbekistan
Madatov Kurbonboy Aminboevich
Department of Surgical Diseases No. 1, Tashkent State Medical University, Uzbekistan
Matmuratov Seyilkhon Kuronboevich
Department of Surgical Diseases No. 1, Tashkent State Medical University, Uzbekistan
Sharopov Asliddin Nasriddinovich
Department of Surgical Diseases No. 1, Tashkent State Medical University, Uzbekistan
Rakhimov Rasulbek Ibrokhimovich
Department of Surgical Diseases No. 1, Tashkent State Medical University, Uzbekistan
tajmspr 2026
VOL. 8 / NO. 2 FEBRUARY
VOLUME 8
ISSUE 2
YEAR 2026
PAGES 128-133

Abstract

This article examines the impact of the Arg122His polymorphism in the PRSS1 gene on the incidence of acute pancreatitis. In the mechanism of acute pancreatitis development, environmental factors play an important role alongside genetic factors. Ethnic differences in the frequency distribution of alleles and genotypes of this gene's polymorphic variant were identified. Further advancement of molecular genetic research through studying the genetic basis of pancreatitis is crucial for developing new diagnostic methods and determining treatment strategies with an individualized approach to each patient.

Keywords

Acute pancreatitis cationic trypsinogen (PRSS1) gene polymorphism

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