Medical Science
| Open Access |
DOI: Circadian Rhythm Alterations And Melatonin Secretion Dynamics In Young Adults With Metabolic Syndrome
Akmal Gaybiyev , Samarkand Medical University, Uzbekistan Shaxboz Bobojonov , Samarkand Medical University, UzbekistanAbstract
Metabolic syndrome (MS) in young adults has emerged as an increasingly prevalent health challenge, with recent studies reporting a 4.8–7.0% occurrence among individuals aged 18–30 years, primarily associated with decreased HDL cholesterol levels. The progressive rise in obesity and related metabolic disorders underscores the importance of early identification of neuroendocrine and circadian disturbances contributing to MS pathogenesis. Melatonin, a key regulator of circadian homeostasis and a potent endogenous antioxidant, plays a crucial role in metabolic regulation, including glucose control, lipid balance, and anti-inflammatory defense. This study examines the features of daily melatonin secretion in young patients with MS, emphasizing its diagnostic and pathogenetic significance. A reduction in nocturnal melatonin release and flattening of its circadian rhythm were observed, correlating with increased insulin resistance, dyslipidemia, and endothelial dysfunction. Altered melatonin excretion patterns, assessed through urinary 6-sulfatoxymelatonin profiles, reflect an early manifestation of chronobiological imbalance or “chronodissonance.” The findings highlight that disruption of melatonin rhythm may serve as an early biomarker of metabolic and vascular risk, supporting the role of circadian regulation in preventive and therapeutic strategies for metabolic syndrome in young adults.
Keywords
Melatonin, metabolic syndrome, circadian rhythm
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Copyright (c) 2025 Akmal Gaybiyev, Shaxboz Bobojonov
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