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Engineering and Technology OPEN ACCESS

A Unified Generative Artificial Intelligence And Digital Twin Framework For Adaptive Healthcare Analytics And Industrial Cyber-Physical Infrastructure Optimization

Dr. Minh Nguyen
Department of Environmental Biotechnology Ho Chi Minh City National University Ho Chi Minh City, Vietnam
Dr. Lan Tran
Faculty of Information Systems Vietnam International Research Institute Da Nang, Vietnam
tajet 2026
VOL. 8 / NO. 4 APRIL
FULL TEXT PP. 141-152
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VOLUME 8
ISSUE 4
YEAR 2026
PAGES 141-152
RESEARCH OVERVIEW

Abstract

The convergence of Generative Artificial Intelligence (Generative AI) and Digital Twin (DT) technologies is redefining the operational dynamics of healthcare ecosystems and industrial cyber-physical infrastructures. Digital twins provide synchronized virtual representations of physical assets, systems, and processes, while Generative AI enables intelligent synthesis, predictive reasoning, adaptive decision-making, and automated optimization. Despite rapid advancements in both domains, existing frameworks remain fragmented, domain-specific, and inadequately aligned with interoperability, cybersecurity, scalability, and standardization requirements. This research proposes a unified Generative AI-enabled Digital Twin framework designed to support adaptive healthcare analytics and industrial cyber-physical infrastructure optimization. The study synthesizes findings from healthcare digital twins, federated learning, edge intelligence, anomaly detection, predictive maintenance, cybersecurity orchestration, and IoT-driven industrial automation. A layered methodological architecture integrating sensor fusion, data orchestration, federated intelligence, digital twin synchronization, explainable AI, and adaptive optimization mechanisms is introduced. The framework addresses critical operational challenges including real-time synchronization, secure edge analytics, multi-domain interoperability, predictive diagnostics, personalized healthcare adaptation, and resilient cyber-physical monitoring.

The research further evaluates the applicability of the proposed architecture across healthcare diagnostics, intelligent manufacturing, smart monitoring systems, battery management systems, and industrial process optimization. Analytical findings indicate that unified AI-DT ecosystems can significantly enhance predictive accuracy, operational resilience, adaptive resource allocation, and decentralized decision intelligence while reducing latency, infrastructure inefficiencies, and cybersecurity vulnerabilities. However, substantial limitations persist regarding data heterogeneity, explainability, privacy preservation, synchronization complexity, and computational overhead. The study contributes a standardization-aligned conceptual and methodological model suitable for next-generation cyber-physical infrastructures and precision healthcare systems. The proposed framework establishes a research foundation for scalable, interpretable, and autonomous AI-integrated digital twin ecosystems.

RESEARCH TOPICS

Keywords

Generative Artificial Intelligence Digital Twin Cyber-Physical Systems Precision Healthcare

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