The present study constitutes a comprehensive scientific work aimed at the development and theoretical–methodological substantiation of standards for delivering nail-service procedures to patients with diabetes mellitus. Against the backdrop of the global epidemiological situation, in which diabetes has been diagnosed in more than 589 million people, the use of conventional aesthetic protocols is associated with a clinically meaningful increase in unjustified risks. Among the most unfavorable outcomes are iatrogenic tissue injury, infectious-inflammatory complications, and the creation of preconditions for amputations. The work integrates advances in endocrinology, dermatology, materials physics (tribology), and psychology, making it possible to formulate a coherent concept of “wet” atraumatic manicure as a safe intervention under conditions of diabetes-associated impairment of trophism and tissue repair. Emphasis is placed on the analysis of thermodynamic parameters of rotary instrument operation, clarification of molecular mechanisms of healing under diabetic skin transformation, and the psychosocial determinants of professional interaction within the “specialist–patient” system. Within the study, evidence-oriented algorithms are proposed for selecting abrasive materials, speed modes, and chemical agents, grounded in the principles of evidence-based medicine and the fundamental laws of friction that determine the nature of contact loads and the probability of microdamage.