Medical Science | Open Access | DOI: https://doi.org/10.37547/tajmspr/Volume08Issue02-25

Characteristics of Clinical Manifestations in Children with Type 1 Diabetes Mellitus After Covid-19 Infection

Sadirkhodjaeva Azizakhon Alavitdinovna , Doctor of Medical Sciences, Associate Professor, Department of Propedeutics of Children's Diseases No. 2 of Tashkent State Medical University, Uzbekistan

Abstract

The purpose of the study: To study the characteristics of clinical indicators in children with type 1 diabetes mellitus after COVID-19 infection. We conducted a study of 254 children with type 1 diabetes who had COVID-19 infection and were treated at the pediatric department of the Republican Specialized Scientific and Practical Medical Center of Endocrinology named after Academician E.H. Turakulov and 30 practically healthy children of the same age and gender. Children with type 1 diabetes mellitus who have experienced COVID-19 infection demonstrate a higher frequency of cardiovascular, autonomic, and neurological manifestations, along with an increased prevalence of chronic diabetic complications, particularly in older age groups. These alterations are likely associated with post-infectious inflammatory responses, endothelial dysfunction, and metabolic disturbances contributing to the progression of microvascular and neurocardiac impairments. These findings indicate that COVID-19 may act as an aggravating factor in the development and progression of chronic complications in pediatric patients with type 1 diabetes mellitus and highlight the importance of early diagnosis, regular cardiological evaluation, and comprehensive multidisciplinary follow-up in the post-COVID period.

Keywords

Type I diabetes mellitus, children, complaints

References

Andersen K.G., Rambaut A., Lipkin W.I., et al. (2022). "The proximal origin of SARS-CoV-2". Nature Medicine, 28(3), 450–455. DOI: 10.1038/s41591-022-01807-4.

Anft M., Paniskaki K., Blazquez-Navarro A., et al. (2022). "COVID-19-Induced ARDS Is Associated with Decreased Frequency of Activated Memory/Effector T Cells Expressing CD11a". Molecular Therapy, 30(12), 3190–3202. [DOI: 10.1016/j.ymthe.2022.09.002]

Brouqui P., Amrane S., Million M., et al. (2022). "COVID-19 re-infection: The role of persistent viral replication". Clinical Microbiology and Infection, 28(2), 225–230. DOI: 10.1016/j.cmi.2021.11.005.

Caccialanza R, Laviano A, Lobascio F, et al. Early nutritional supplementation in non‐critically ill patients hospitalized for the 2019 novel coronavirus disease (COVID‐19): rationale and feasibility of a shared pragmatic protocol. Nutrition. 2020; 74:110835.

Cherubini V, Gohil A, Addala A, Beck RW, Maahs DM, Skyler JS, et al. Unintended consequences of coronavirus disease-2019: Remember general pediatrics. J Pediatr. 2021;223:197–198.

Daniels CJ, Rajpal S, Greenshields JT, Rosenthal GL, Chung EH, Terrin M, et al. Prevalence of clinical and subclinical myocarditis in competitive athletes with recent SARS-CoV-2 infection. JAMA Cardiol. 2021;6(9):1078–1087.

Ferretti L., Wymant C., Kendall M., et al. (2021). "Quantifying SARS-CoV-2 transmission suggests epidemic control with digital contact tracing". Science, 368(6491), eabb6936. DOI: 10.1126/science.abb6936.

Grasselli G., Pesenti A., Cecconi M. (2022). "Critical care utilization for the COVID-19 outbreak in Lombardy, Italy: early experience and forecast during an emergency response". JAMA Internal Medicine, 325(4), 1574–1582. DOI: 10.1001/jama.2021.4031.

Rubino F, Amiel SA, Zimmet P, Alberti G, Bornstein S, Eckel RH, et al. New-onset diabetes in Covid-19. N Engl J Med. 2020;383(8):789–790.

Wang J, Li X, Cao G, Wu X, Wang Z, Yan T. COVID-19 in children with diabetes: Clinical characteristics and outcomes. Diabetes Res Clin Pract. 2021;177:108928.

Download and View Statistics

Views: 0   |   Downloads: 0

Copyright License

Download Citations

How to Cite

Sadirkhodjaeva Azizakhon Alavitdinovna. (2026). Characteristics of Clinical Manifestations in Children with Type 1 Diabetes Mellitus After Covid-19 Infection. The American Journal of Medical Sciences and Pharmaceutical Research, 8(2), 168–171. https://doi.org/10.37547/tajmspr/Volume08Issue02-25