Studies were conducted to study the toxicological effects: safety and cumulative effect of a new combined dosage form in the form of gels based on benzketosone and papaya extract.  Experiments were performed on oral wounds and cutaneous wounds in an experiment on rats. A comparative analysis of the wound-healing effect of the new composition of gels "Benzpaya" was carried out with the comparison preparations gels Asepta and Salcoseril, the advantage of the former was revealed. The developed gel can become an alternative tool in the treatment and prevention of dental diseases with minimal risk of side effects. The new composition of gels "Benzpaya" in a dose of 150 mg / kg has a wound-healing effect, which reduces the time of cleansing and wound healing by 4-8 days. A comparative analysis with the comparison drugsgeli Asepta and Salcoseril revealed the advantage of the former.

 The results of studying the acute toxicity of the new composition of gels "Benzpaya-S" showed that they belong to the VI class of relatively harmless substances. LD5050in mice when administered into the oral cavity was more ≥than ≥5000 mg/kg. There is also a lack of not only cumulative action,but also habituation.

Dental diseases, nonsteroidal anti-inflammatory drugs, phenylglyaxic acid

Dental diseases (Stomatitis, Gingivitis) https:// www/sm-stomatology.ru/

Study of dental gel with dry extract and camel thorn.Akhmetkand.A., Turgunbayeva A. A., Burasheva G. Sh., Ustenova G. O. Collection of Mat. XIII-th Intern. scientific and practical conferences "Priorities of Pharmacy and Dentistry: from theory to practice" dedicated. to the 135th anniversary of S. D. Asfendiyarov, NAO KazNMU, Alma-Ata, 2024-pp. 1-21.

Sapovskaya A.V., Sampiev A.M., Nikiforova E. B. Actual issues, nomenclatures, properties and technologies of dental gels //Modern problems of science and education.-2015. - No. 1. - p. 128

Zakirov U. B., Maksudov A. A., Azizov U. M. Study of the effectiveness of benzketozone in the treatment of eye burns. Pharmaceutical magazine. Tashkent, 2004; 1: 90-92.

5.Pharmacopoeia. Petrol filling station. 42 Уз-0850-2010,42-Уз-0850-2020

Tillaeva U.M., Nazarkulov M.S., Rahmanov Z.A., Tillaeva G,U., Gaibnazarova D.T. Analysis of drugs containing enzymes in the pharmaceutical market of the republic of Uzbekistan. World journal of Pharmaceutical and life sciences. 2020;6(1):01-04.

Methods of testing the effects of chemical products on the human body. Acute oral toxicity-method for determining the class of acute toxicity. (OECD, Test No. 423: 2001,IDT) Minsk 2013.

Methodological recommendations for the preclinical study of dermatotropic medicinal products /Guidelines for conducting preclinical studies of medicinal products. Part One, Moscow, 2012, pp. 738-746. Mironova A. N.

Glyantsev S. P., Annaeva A. G., Savina T. V. Morphological substantiation of the choice of composition and structure of biologically active composition based on sodium analginate for the treatment of wounds. biol. and medicine. 1999. No. 1. pp. 65-67.

C.Y. Hsu, M.J. Saadh, A.F. Mutee, H. Mumtaz, G.U. Tillaeva, M. Mirzaei, M. Da’i, F. Mascarenhas-Melo, M.M. Salem-Bekhit. Assessing the metronidazole adsorption by an iron-enhanced nanocone along with DFT calculations regarding the conjugated system formations for developing the drug delivery platforms,Inorganic Chemistry Communications,Volume 165,2024,112496,ISSN 1387-7003,https://doi.org/10.1016/j.inoche.2024.112496.

M.C. Bautista, D. Cort´es-Arriagada, E. Shakerzadeh, E.C. Anota, Acetylsalicylic acid interaction with Boron nitride nanostructures–a density functional analysis, J. Mol. Liq. 355 (2022) 118980.