Articles | Open Access | DOI: https://doi.org/10.37547/TAJMSPR/Volume05Issue07-06

EFFECTS OF PERINDOPRIL INITIATION ON SERUM CREATININE AND POTASSIUM LEVELS FOLLOWING ACUTE CORONARY SYNDROME (ACS)

Ezazaya Sukesh , Pharmacy Department, Hospital Sultan Ismail, Johor, Malaysia

Abstract

Perindopril, an angiotensin-converting enzyme (ACE) inhibitor, is commonly prescribed as a cardioprotective medication following acute coronary syndrome (ACS). However, concerns have been raised regarding its potential impact on renal function and serum potassium levels. This study aimed to investigate the effects of perindopril initiation on serum creatinine and potassium levels in patients with ACS.

Keywords

Perindopril, Acute coronary syndrome (ACS), Serum creatinine

References

D. P. Bicket, “Using ACE inhibitors appropriately,” American family physician, vol. 66, issue 3, pp. 461-8, 2002.

The Europa Trial Investigators, “Efficacy of perindopril in reduction of cardiovascular events among patients with stable coronary artery diseases: a randomised double blind, placebo controlled, multicenter trial (the EUROPA study),” The Lancet, vol. 362, issue 9, pages 782-88, 2003.

R. Ferrari, “Effects of angiotensin-converting enzyme inhibition with perindopril on left ventricular remodeling and clinical outcome: results of the randomized perindopril and remodeling in elderly with acute myocardial infarction (PREAMI) study,” Arch Intern Med, vol. 166, issue 6, pp. 659-66, 2006.

Management of Chronic Kidney Disease in Adults, 2nd ed., Ministry of Health., Putrajaya., WP, 2018.

Hypertension in Adults: diagnosis and management, National Institute for Health and Clinical Excellence., 2011.

Chronic kidney disease in adults: assessment and management, National Institute for Health and Clinical Excellence., 2014.

M. Schmidt, K. E. Mansfield, K. Bhaskaran, D. Nitsch, H. T. Sørensen, L. Smeeth, L. A. Tomlinson, “Adherence to guidelines for creatinine and potassium monitoring and discontinuation following renin-angiotensin system blockade: a UK general practice-based cohort study,” BMJ Open, 2017.

J. S. Hurley, M. Roberts, L. I. Solberg, M. J. Gunter, W. W. Nelson, L. Young, F. J. Frost, “Laboratory safety monitoring of chronic medications in ambulatory care settings,” J Gen Intern Med, vol. 20, issue 4, pages 331-333, 2005.

J. E. Bootsma, M. F. W. Herwaarden, A. L. M. Verbeek, P. Füssenich, P. A. G. M. D. Smet, M. G. O. Rikkert, C. Kramers, “Adherence to biochemical monitoring recommendations in patients starting with renin angiotensin system inhibitors: a retrospective cohort study in the Netherlands,” Drug Saf, vol. 34, issue 7, pages 605-14, 2011.

G. L. Bakris, M. R. Weir, “ Angiotensin-converting enzyme inhibitor– associated elevations in serum creatinine: is this a cause for concern?,” Arch Intern Med., vol. 160, issue 5, pages 685-93, 2000.

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How to Cite

Ezazaya Sukesh. (2023). EFFECTS OF PERINDOPRIL INITIATION ON SERUM CREATININE AND POTASSIUM LEVELS FOLLOWING ACUTE CORONARY SYNDROME (ACS). The American Journal of Medical Sciences and Pharmaceutical Research, 5(07), 27–29. https://doi.org/10.37547/TAJMSPR/Volume05Issue07-06