Gram-negative microorganisms has showed up from an organic entity of unsure pathogenecity towards an infective specialist . Among nonfermenting bacterium A. baumannii is that the second-most-regularly segregated life forms in human. The quick escalate of their protection from anti-infection agents, particularly worldwide rise and stretch out of Gram-negative microscopic organisms strains insusceptible to meropenem more confined the restorative other options. during this study we assess the portion of resistivity of Gram-negative microscopic organisms against meropenem anti-microbials at North Dakota State College, Fargo. Absolute 439 disengages of Gram-negative microorganisms were gathered from various clinical examples of hospitalized patients from January to December 2020, distinguished by standard microbiological techniques. Antibiograms were finished on Mueller-Hinton agar plates with circle dispersion technique (Kirby Bauer strategy). Plate tried: Meropenem (10 µg/circle). The outcomes were deciphered reliable with the guidelines of the Clinical and Research center Principles Establishment. (CLSI). Among 439 examples, 300 (68.3%) examples were safe to Meropenem and in this manner the excess that is 139 (31.7%) showed aversion to the medications. In immature nations including Joined Express the happiness of multidrug obstruction and their dispersal in Gram-negative microorganisms species is definitely not a simple assignment.