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Applied Sciences OPEN ACCESS

Toxicological Characteristics Of N-Deacetyllappaconitine Under Chronic Administration In White Rats

Lola Tishaevna Zakhidova
Institute Of Chemistry Of Plant Substances, Academy Of Sciences Of Republic Of Uzbekistan, Tashkent
Dilfuza Mir-Takhirovna Saidkhodjaeva
Institute Of Chemistry Of Plant Substances, Academy Of Sciences Of Republic Of Uzbekistan, Tashkent
Tolmas Tolibovich Khamroev
Institute Of Chemistry Of Plant Substances, Academy Of Sciences Of Republic Of Uzbekistan, Tashkent
Zafar Isomiddinovich Sanoev
Institute Of Chemistry Of Plant Substances, Academy Of Sciences Of Republic Of Uzbekistan, Tashkent
Visola Farmanovna Tukhtasheva
Institute Of Chemistry Of Plant Substances, Academy Of Sciences Of Republic Of Uzbekistan, Tashkent
Hilola Akhmedjanovna Rakhmanova
Institute Of Chemistry Of Plant Substances, Academy Of Sciences Of Republic Of Uzbekistan, Tashkent
tajas 2021
VOL. 3 / NO. 3 MARCH
VOLUME 3
ISSUE 3
YEAR 2021
PAGES 34-41

Abstract

In chronic experiments in laboratory animals, studied toxicological perspective new antiarrhythmic effect of N-deacetyllappaconitine for the treatment of arrhythmic states, an original herbal preparation based on Aconitum leucostonum, Ac.Septentrionale was created. During 2,5 months of intragastric administration in animals exposed to all doses of N-deacetyllappaconitine, no deviations in the parameters of the functioning of the nervous system were found, therefore, this value is the lowest effective (threshold) dose in a chronic experiment.

Keywords

N-deacetyllappaconitine chronic experiments central nervous system biochemical parameters

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